Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 1.152


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPB1chr15_-_484345670.401.3e-01Click!
GABPAchr21_+_260291280.253.4e-01Click!
ELK1chrX_-_47394937-0.233.9e-01Click!
ELK4chr1_-_2038686220.234.0e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr20_-_49008445 5.940 NM_003859
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr8_+_38153453 4.343 BAG4
BCL2-associated athanogene 4
chr9_-_37775064 3.524 NM_016042
NM_001002269
EXOSC3

exosome component 3

chr9_-_37775052 3.471 EXOSC3
exosome component 3
chr6_-_166676016 3.318 SFT2D1
SFT2 domain containing 1
chrX_+_150316332 3.153 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_118273887 3.074 NM_006784
WDR3
WD repeat domain 3
chr7_-_128482059 3.028 TNPO3
transportin 3
chr6_-_28475478 2.983 NM_001163391
ZSCAN12
zinc finger and SCAN domain containing 12
chr9_-_37774785 2.966 EXOSC3
exosome component 3
chr11_+_118394350 2.903 NM_016146
TRAPPC4
trafficking protein particle complex 4
chr7_-_128482417 2.893 NM_001191028
NM_012470
TNPO3

transportin 3

chr8_+_38153514 2.865 BAG4
BCL2-associated athanogene 4
chr1_-_32888677 2.860 NM_178547
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr10_-_15942461 2.855 NM_024948
FAM188A
family with sequence similarity 188, member A
chr3_+_15444056 2.796 NM_033083
EAF1
ELL associated factor 1
chr6_+_170705345 2.766 NM_001172085
NM_003194
TBP

TATA box binding protein

chr3_+_32701663 2.766 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr2_-_174968595 2.751 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr11_+_118394703 2.742 TRAPPC4
trafficking protein particle complex 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 207 entries
enrichment   p-value GO term description
3.04 3.26e-02 GO:0006362 transcription elongation from RNA polymerase I promoter
2.96 7.75e-05 GO:0000245 spliceosome assembly
2.87 2.39e-02 GO:0006360 transcription from RNA polymerase I promoter
2.87 2.39e-02 GO:0006361 transcription initiation from RNA polymerase I promoter
2.84 1.97e-03 GO:0000387 spliceosomal snRNP assembly
2.65 1.90e-04 GO:0006369 termination of RNA polymerase II transcription
2.62 4.01e-09 GO:0006353 transcription termination, DNA-dependent
2.61 2.65e-02 GO:0009452 RNA capping
2.52 2.21e-09 GO:0071826 ribonucleoprotein complex subunit organization
2.52 9.65e-09 GO:0022618 ribonucleoprotein complex assembly
2.51 2.62e-03 GO:0006283 transcription-coupled nucleotide-excision repair
2.48 6.19e-08 GO:0000216 M/G1 transition of mitotic cell cycle
2.47 1.73e-05 GO:0006368 transcription elongation from RNA polymerase II promoter
2.44 3.84e-07 GO:0006354 transcription elongation, DNA-dependent
2.41 4.67e-04 GO:0006521 regulation of cellular amino acid metabolic process
2.38 5.28e-19 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.38 5.28e-19 GO:0000398 nuclear mRNA splicing, via spliceosome
2.36 5.22e-19 GO:0000375 RNA splicing, via transesterification reactions
2.35 3.88e-07 GO:0006415 translational termination
2.35 3.69e-03 GO:0050434 positive regulation of viral transcription

Gene overrepresentation in compartment category:

Showing 1 to 20 of 67 entries
enrichment   p-value GO term description
2.87 4.25e-03 GO:0005689 U12-type spliceosomal complex
2.79 2.87e-04 GO:0030532 small nuclear ribonucleoprotein complex
2.71 5.01e-12 GO:0071013 catalytic step 2 spliceosome
2.54 4.10e-17 GO:0005681 spliceosomal complex
2.42 1.32e-02 GO:0022627 cytosolic small ribosomal subunit
2.35 1.87e-05 GO:0000502 proteasome complex
2.34 1.74e-06 GO:0022626 cytosolic ribosome
2.30 6.83e-03 GO:0015030 Cajal body
2.21 2.36e-03 GO:0005798 Golgi-associated vesicle
2.14 1.57e-04 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.09 5.01e-03 GO:0015934 large ribosomal subunit
2.06 3.10e-04 GO:0000790 nuclear chromatin
2.02 3.32e-30 GO:0030529 ribonucleoprotein complex
2.00 1.73e-02 GO:0044450 microtubule organizing center part
1.99 5.87e-07 GO:0000151 ubiquitin ligase complex
1.95 3.74e-07 GO:0044445 cytosolic part
1.94 1.37e-08 GO:0005840 ribosome
1.92 4.19e-05 GO:0016607 nuclear speck
1.87 3.95e-09 GO:0016604 nuclear body
1.85 1.20e-02 GO:0042470 melanosome

Gene overrepresentation in function category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
2.15 3.50e-02 GO:0003743 translation initiation factor activity
2.03 1.02e-03 GO:0008135 translation factor activity, nucleic acid binding
1.95 1.11e-06 GO:0003735 structural constituent of ribosome
1.85 2.59e-02 GO:0008565 protein transporter activity
1.80 1.06e-02 GO:0008026 ATP-dependent helicase activity
1.80 1.06e-02 GO:0070035 purine NTP-dependent helicase activity
1.79 6.87e-04 GO:0004386 helicase activity
1.77 1.59e-06 GO:0004842 ubiquitin-protein ligase activity
1.76 8.48e-07 GO:0019787 small conjugating protein ligase activity
1.74 2.66e-26 GO:0003723 RNA binding
1.72 3.25e-02 GO:0051082 unfolded protein binding
1.70 1.04e-03 GO:0008168 methyltransferase activity
1.68 2.63e-06 GO:0016881 acid-amino acid ligase activity
1.65 3.66e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.64 3.11e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.56 1.36e-07 GO:0016874 ligase activity
1.51 4.17e-03 GO:0042623 ATPase activity, coupled
1.44 3.11e-03 GO:0003712 transcription cofactor activity
1.44 3.64e-03 GO:0000988 protein binding transcription factor activity
1.44 3.64e-03 GO:0000989 transcription factor binding transcription factor activity