Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 1.152


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPB1chr15_-_484345670.401.3e-01Click!
GABPAchr21_+_260291280.253.4e-01Click!
ELK1chrX_-_47394937-0.233.9e-01Click!
ELK4chr1_-_2038686220.234.0e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_-_49008445 5.940 NM_003859
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr8_+_38153453 4.343 BAG4
BCL2-associated athanogene 4
chr9_-_37775064 3.524 NM_016042
NM_001002269
EXOSC3

exosome component 3

chr9_-_37775052 3.471 EXOSC3
exosome component 3
chr6_-_166676016 3.318 SFT2D1
SFT2 domain containing 1
chrX_+_150316332 3.153 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_118273887 3.074 NM_006784
WDR3
WD repeat domain 3
chr7_-_128482059 3.028 TNPO3
transportin 3
chr6_-_28475478 2.983 NM_001163391
ZSCAN12
zinc finger and SCAN domain containing 12
chr9_-_37774785 2.966 EXOSC3
exosome component 3
chr11_+_118394350 2.903 NM_016146
TRAPPC4
trafficking protein particle complex 4
chr7_-_128482417 2.893 NM_001191028
NM_012470
TNPO3

transportin 3

chr8_+_38153514 2.865 BAG4
BCL2-associated athanogene 4
chr1_-_32888677 2.860 NM_178547
ZBTB8OS
zinc finger and BTB domain containing 8 opposite strand
chr10_-_15942461 2.855 NM_024948
FAM188A
family with sequence similarity 188, member A
chr3_+_15444056 2.796 NM_033083
EAF1
ELL associated factor 1
chr6_+_170705345 2.766 NM_001172085
NM_003194
TBP

TATA box binding protein

chr3_+_32701663 2.766 NM_015442
CNOT10
CCR4-NOT transcription complex, subunit 10
chr2_-_174968595 2.751 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr11_+_118394703 2.742 TRAPPC4
trafficking protein particle complex 4
chr7_-_128482354 2.738 TNPO3
transportin 3
chr2_+_74007439 2.719 NM_080916
NM_080918
DGUOK

deoxyguanosine kinase

chr4_-_140224914 2.708 NM_006874
ELF2
E74-like factor 2 (ets domain transcription factor)
chr21_-_32906729 2.694 NM_021254
C21orf59
chromosome 21 open reading frame 59
chr2_+_233825084 2.694 ATG16L1
ATG16 autophagy related 16-like 1 (S. cerevisiae)
chr8_+_38153223 2.685 NM_004874
BAG4
BCL2-associated athanogene 4
chr7_+_102775309 2.676 NM_002803
PSMC2
proteasome (prosome, macropain) 26S subunit, ATPase, 2
chr2_+_97628929 2.649 NM_001862
COX5B
cytochrome c oxidase subunit Vb
chr15_+_63948823 2.626 NM_004663
RAB11A
RAB11A, member RAS oncogene family
chr15_-_63596656 2.623 NM_197960
DPP8
dipeptidyl-peptidase 8
chr6_-_166675980 2.623 NM_145169
SFT2D1
SFT2 domain containing 1
chr1_+_181708235 2.622 SMG7
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr10_-_43212681 2.612 HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr2_+_74007495 2.602 DGUOK
deoxyguanosine kinase
chr4_-_140224794 2.536 ELF2
E74-like factor 2 (ets domain transcription factor)
chr3_+_151747266 2.534 EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr1_+_40496508 2.525 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr5_+_69732561 2.522 SMA4
glucuronidase, beta pseudogene
chr1_+_181708068 2.510 NM_001174061
NM_173156
NM_201568
NM_201569
SMG7



Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)



chrX_-_7855400 2.506 NM_004650
PNPLA4
patatin-like phospholipase domain containing 4
chr1_-_54291378 2.463 TMEM59
transmembrane protein 59
chr2_+_113648036 2.461 PSD4
pleckstrin and Sec7 domain containing 4
chr17_+_72596349 2.421 SEC14L1
C17orf86
SEC14-like 1 (S. cerevisiae)
chromosome 17 open reading frame 86
chr22_-_17799177 2.386 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr9_-_67945114 2.364 LOC283788
LOC642236
FSHD region gene 1 pseudogene
FSHD region gene 1 pseudogene
chr19_+_63386256 2.360 ZNF274
zinc finger protein 274
chrX_-_7855764 2.358 NM_001142389
NM_001172672
PNPLA4

patatin-like phospholipase domain containing 4

chr1_-_32460526 2.338 TMEM234
transmembrane protein 234
chr20_+_21231921 2.326 NM_012255
XRN2
5'-3' exoribonuclease 2
chr22_-_17799215 2.309 NM_003325
HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_+_74007523 2.283 DGUOK
deoxyguanosine kinase
chr10_-_1092643 2.265 IDI1
isopentenyl-diphosphate delta isomerase 1
chr16_-_52094613 2.246 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr16_-_70400232 2.245 AP1G1
adaptor-related protein complex 1, gamma 1 subunit
chr16_-_67930974 2.244 NM_032382
COG8
component of oligomeric golgi complex 8
chr22_-_17798998 2.242 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr17_-_17125214 2.241 COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr11_+_117735558 2.198 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr9_-_37775013 2.189 EXOSC3
exosome component 3
chr14_+_95899541 2.188 C14orf129
chromosome 14 open reading frame 129
chr2_-_98591337 2.187 NM_001008215
C2orf64
chromosome 2 open reading frame 64
chr6_-_153365564 2.185 NM_001114184
NM_019041
MTRF1L

mitochondrial translational release factor 1-like

chr15_-_63597073 2.182 NM_017743
NM_130434
NM_197961
DPP8


dipeptidyl-peptidase 8


chr22_+_17799341 2.176 MRPL40
mitochondrial ribosomal protein L40
chr20_-_2399428 2.167 SNRPB
small nuclear ribonucleoprotein polypeptides B and B1
chr10_-_43212703 2.152 NM_001098207
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr2_+_128565269 2.146 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr2_+_37312277 2.142 NM_001083946
NM_144736
C2orf56

chromosome 2 open reading frame 56

chr21_-_32906528 2.139 C21orf59
chromosome 21 open reading frame 59
chr5_+_74098828 2.136 NM_014886
NSA2
NSA2 ribosome biogenesis homolog (S. cerevisiae)
chr2_+_98591516 2.121 UNC50
unc-50 homolog (C. elegans)
chr3_-_15443985 2.118 NM_152396
METTL6
methyltransferase like 6
chr22_+_20350272 2.110 NM_014337
NM_148175
NM_148176
PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr16_-_48960186 2.076 NM_001173984
NM_013263
BRD7

bromodomain containing 7

chr2_+_64605049 2.076 AFTPH
aftiphilin
chr2_-_20413838 2.059 PUM2
pumilio homolog 2 (Drosophila)
chr3_-_168935287 2.057 NM_007217
NM_145860
NM_145859
PDCD10


programmed cell death 10


chr11_+_117735530 2.055 UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr5_+_158622843 2.052 UBLCP1
ubiquitin-like domain containing CTD phosphatase 1
chr5_+_134012133 2.046 NM_021982
SEC24A
SEC24 family, member A (S. cerevisiae)
chr15_-_63597025 2.042 DPP8
dipeptidyl-peptidase 8
chr7_-_99355085 2.031 NM_033017
NM_033091
TRIM4

tripartite motif containing 4

chr1_-_224441023 2.023 ACBD3
acyl-CoA binding domain containing 3
chr2_+_176842368 2.022 NM_006554
MTX2
metaxin 2
chr2_-_201461945 2.020 NM_032472
NM_130906
PPIL3

peptidylprolyl isomerase (cyclophilin)-like 3

chr16_+_56054070 2.017


chr4_-_101086754 2.010 DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr5_-_87600371 1.962 NM_153354
TMEM161B
transmembrane protein 161B
chr8_+_104496766 1.944 DCAF13
DDB1 and CUL4 associated factor 13
chr1_+_178118518 1.944 TOR1AIP1
torsin A interacting protein 1
chr20_+_60395515 1.939 NM_001024
RPS21
ribosomal protein S21
chr6_-_36950520 1.935 PPIL1
peptidylprolyl isomerase (cyclophilin)-like 1
chr3_+_151747204 1.931 NM_032025
EIF2A
eukaryotic translation initiation factor 2A, 65kDa
chr11_-_18504939 1.923 NM_006292
TSG101
tumor susceptibility gene 101
chr17_-_17125314 1.913 NM_003653
COPS3
COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr3_+_88281582 1.911 NM_173824
C3orf38
chromosome 3 open reading frame 38
chr16_-_20725272 1.907 NM_001142725
NM_080663
ERI2

ERI1 exoribonuclease family member 2

chr6_-_108689000 1.905 NM_003795
NM_152827
SNX3

sorting nexin 3

chr1_-_17637576 1.903 RCC2
regulator of chromosome condensation 2
chr2_-_230494862 1.896 NM_004238
TRIP12
thyroid hormone receptor interactor 12
chr6_-_153365532 1.893 MTRF1L
mitochondrial translational release factor 1-like
chr6_-_108688918 1.889 SNX3
sorting nexin 3
chr17_+_38238970 1.886 PSME3
proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr6_+_43711566 1.876 MAD2L1BP
MAD2L1 binding protein
chr1_+_36169260 1.870 NM_024852
NM_177422
EIF2C3

eukaryotic translation initiation factor 2C, 3

chr5_+_324764 1.861 PDCD6
programmed cell death 6
chr7_+_107171809 1.860 CBLL1
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
chr14_+_75687997 1.851 NM_017926
NM_017972
C14orf118

chromosome 14 open reading frame 118

chr1_+_22224571 1.851 HSPC157
hypothetical LOC29092
chr9_+_130124873 1.845 COQ4
coenzyme Q4 homolog (S. cerevisiae)
chr16_-_30301634 1.837 NM_052838
SEPT1
septin 1
chr16_+_20725511 1.836 LOC81691
exonuclease NEF-sp
chr7_-_99355051 1.832 TRIM4
tripartite motif containing 4
chr2_-_27147995 1.829 NM_001134693
OST4
oligosaccharyltransferase 4 homolog (S. cerevisiae)
chr19_+_62443784 1.829 ZNF805
zinc finger protein 805
chr10_+_71060008 1.828 NM_145306
C10orf35
chromosome 10 open reading frame 35
chr6_+_160068553 1.828 WTAP
Wilms tumor 1 associated protein
chr2_+_113648020 1.824 NM_012455
PSD4
pleckstrin and Sec7 domain containing 4
chrX_-_130792297 1.820 LOC286467
hypothetical LOC286467
chr10_+_43421860 1.815 NM_145312
ZNF485
zinc finger protein 485
chr18_-_802268 1.815 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr12_-_70343656 1.809


chr16_+_67931178 1.800 NIP7
nuclear import 7 homolog (S. cerevisiae)
chr20_+_42947754 1.797 NM_003404
NM_139323
YWHAB

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

chr4_-_101086891 1.797 NM_001031723
DNAJB14
DnaJ (Hsp40) homolog, subfamily B, member 14
chr16_+_20725267 1.794 NM_001144924
NM_001199053
NM_030941
LOC81691


exonuclease NEF-sp


chr5_+_132230214 1.791 NM_014402
UQCRQ
ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa
chr4_+_41687249 1.785 NM_006345
SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr6_+_30402599 1.785 NM_021253
TRIM39
tripartite motif containing 39
chr7_+_98844480 1.785 NM_003910
BUD31
BUD31 homolog (S. cerevisiae)
chr2_+_37312318 1.783 C2orf56
chromosome 2 open reading frame 56
chr17_+_38403935 1.775 NM_000988
RPL27
ribosomal protein L27
chr1_+_19796119 1.774


chr6_+_160068544 1.773 WTAP
Wilms tumor 1 associated protein
chrX_+_150316313 1.767 NM_001017980
VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr14_-_23781328 1.766 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr7_-_16651885 1.763 NM_020319
ANKMY2
ankyrin repeat and MYND domain containing 2
chr6_-_127706384 1.758 NM_001002030
NM_001105544
NM_001105545
NM_018479
ECHDC1



enoyl CoA hydratase domain containing 1



chrX_+_150316351 1.755 VMA21
VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)
chr1_+_93584078 1.754 DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr5_+_140051198 1.754 NM_012208
HARS2
histidyl-tRNA synthetase 2, mitochondrial (putative)
chr4_+_119825983 1.748 NM_020961
METTL14
methyltransferase like 14
chr16_-_67930907 1.742 COG8
component of oligomeric golgi complex 8
chr1_-_29380969 1.734 SRSF4
serine/arginine-rich splicing factor 4
chr1_-_3702908 1.733 NM_020710
LRRC47
leucine rich repeat containing 47
chr6_+_43711532 1.729 NM_014628
MAD2L1BP
MAD2L1 binding protein
chr7_-_135312574 1.726 MTPN
myotrophin
chr9_-_85761472 1.723 NM_032307
C9orf64
chromosome 9 open reading frame 64
chr5_+_157090900 1.720 NM_017872
THG1L
tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr6_-_153365542 1.720 MTRF1L
mitochondrial translational release factor 1-like
chr18_+_8599670 1.720


chr20_-_47238082 1.717 STAU1
staufen, RNA binding protein, homolog 1 (Drosophila)
chr12_-_122415327 1.711 SBNO1
strawberry notch homolog 1 (Drosophila)
chr9_+_70509925 1.711 NM_003558
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr6_-_125664913 1.709 NM_016063
HDDC2
HD domain containing 2
chr16_+_84390816 1.709 COX4I1
cytochrome c oxidase subunit IV isoform 1
chr20_+_42947764 1.708 YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
chr14_+_75688025 1.707 C14orf118
chromosome 14 open reading frame 118
chr5_+_138705445 1.707 PAIP2
poly(A) binding protein interacting protein 2
chr7_-_99355065 1.706 TRIM4
tripartite motif containing 4
chr7_+_5051977 1.702 NM_021163
RBAK
RB-associated KRAB zinc finger
chr5_-_32348826 1.696 NM_001040446
MTMR12
myotubularin related protein 12
chr6_+_160068531 1.694 WTAP
Wilms tumor 1 associated protein
chr10_+_12278185 1.689 CDC123
cell division cycle 123 homolog (S. cerevisiae)
chr11_+_117735502 1.685 NM_004788
UBE4A
ubiquitination factor E4A (UFD2 homolog, yeast)
chr15_-_72540543 1.684 NM_032907
NM_201265
UBL7

ubiquitin-like 7 (bone marrow stromal cell-derived)

chr2_-_136459546 1.684 DARS
aspartyl-tRNA synthetase
chr1_-_220829704 1.683 NM_005681
NM_139352
TAF1A

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa

chr6_+_139136349 1.680 NM_015439
CCDC28A
coiled-coil domain containing 28A
chr1_+_181708272 1.674 SMG7
Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
chr7_+_6583560 1.673 NM_001134387
NM_001134388
NM_001134389
NM_018106
ZDHHC4



zinc finger, DHHC-type containing 4



chr15_-_72540518 1.672 UBL7
ubiquitin-like 7 (bone marrow stromal cell-derived)
chr4_+_41687304 1.671 SLC30A9
solute carrier family 30 (zinc transporter), member 9
chr2_-_96334996 1.671 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr5_+_72830003 1.665 NM_001037637
NM_001207
BTF3

basic transcription factor 3

chr6_+_30402203 1.663


chr19_-_61324412 1.653 ZNF787
zinc finger protein 787
chr13_+_52124831 1.646 NM_001130912
NM_006704
SUGT1

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)

chr5_+_36912656 1.645 NIPBL
Nipped-B homolog (Drosophila)
chr20_+_33593243 1.642 ERGIC3
ERGIC and golgi 3
chr2_-_25954677 1.641 ASXL2
additional sex combs like 2 (Drosophila)
chr22_-_40408331 1.631 NM_005008
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr20_-_2399439 1.628 NM_003091
NM_198216
SNRPB

small nuclear ribonucleoprotein polypeptides B and B1

chr2_-_240724373 1.628 NM_001163424
NM_138336
MYEOV2

myeloma overexpressed 2

chr11_+_123997980 1.627 TBRG1
transforming growth factor beta regulator 1
chr14_+_75688042 1.626 C14orf118
chromosome 14 open reading frame 118
chr8_+_11179724 1.622 MTMR9
myotubularin related protein 9
chr6_+_160068598 1.619 NM_152857
WTAP
Wilms tumor 1 associated protein
chr16_-_11917419 1.613 GSPT1
G1 to S phase transition 1
chr2_-_136459659 1.613 NM_001349
DARS
aspartyl-tRNA synthetase
chr9_+_114289178 1.611 KIAA1958
KIAA1958
chr2_+_9481224 1.603 CPSF3
cleavage and polyadenylation specific factor 3, 73kDa
chr6_-_108688860 1.601 SNX3
sorting nexin 3
chr16_+_67931033 1.601 NM_016101
NIP7
nuclear import 7 homolog (S. cerevisiae)
chr10_-_79459296 1.600 NM_007055
POLR3A
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr4_+_191098967 1.596 NM_004477
FRG1
FSHD region gene 1
chr2_-_54051290 1.592 NM_014614
PSME4
proteasome (prosome, macropain) activator subunit 4
chr5_-_130998806 1.589 NM_001164386
NM_001164387
NM_001164388
NM_001164389
NM_001164390
NM_016340
RAPGEF6





Rap guanine nucleotide exchange factor (GEF) 6





chr1_+_93584064 1.587 NM_001938
DR1
down-regulator of transcription 1, TBP-binding (negative cofactor 2)
chr12_-_92360117 1.580 NM_003348
UBE2N
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.43 2.15e-61 GO:0044260 cellular macromolecule metabolic process
1.35 1.92e-48 GO:0043170 macromolecule metabolic process
1.57 1.52e-43 GO:0090304 nucleic acid metabolic process
1.49 9.63e-43 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.28 4.12e-42 GO:0044237 cellular metabolic process
1.58 4.00e-34 GO:0016070 RNA metabolic process
1.38 4.05e-31 GO:0034641 cellular nitrogen compound metabolic process
1.53 5.63e-31 GO:0010467 gene expression
1.44 3.36e-30 GO:0044267 cellular protein metabolic process
1.23 5.50e-30 GO:0044238 primary metabolic process
1.21 9.81e-30 GO:0008152 metabolic process
1.36 1.20e-28 GO:0006807 nitrogen compound metabolic process
1.91 1.91e-28 GO:0006396 RNA processing
1.99 7.52e-28 GO:0016071 mRNA metabolic process
2.10 3.05e-26 GO:0016032 viral reproduction
1.35 3.77e-21 GO:0071841 cellular component organization or biogenesis at cellular level
2.03 3.95e-21 GO:0006397 mRNA processing
1.83 5.69e-21 GO:0000278 mitotic cell cycle
1.46 9.13e-21 GO:0034645 cellular macromolecule biosynthetic process
1.46 1.06e-20 GO:0009059 macromolecule biosynthetic process
1.60 3.34e-20 GO:0007049 cell cycle
1.32 7.85e-20 GO:0019538 protein metabolic process
2.13 1.01e-19 GO:0008380 RNA splicing
1.45 3.42e-19 GO:0006996 organelle organization
2.36 5.22e-19 GO:0000375 RNA splicing, via transesterification reactions
2.38 5.28e-19 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.38 5.28e-19 GO:0000398 nuclear mRNA splicing, via spliceosome
1.71 1.35e-18 GO:0022403 cell cycle phase
1.28 2.03e-18 GO:0071840 cellular component organization or biogenesis
1.82 3.85e-18 GO:0006974 response to DNA damage stimulus
1.63 2.90e-17 GO:0022402 cell cycle process
1.32 2.14e-16 GO:0071842 cellular component organization at cellular level
1.71 2.85e-16 GO:0009057 macromolecule catabolic process
2.27 6.25e-16 GO:0022613 ribonucleoprotein complex biogenesis
1.76 6.52e-16 GO:0044265 cellular macromolecule catabolic process
2.22 1.91e-15 GO:0071843 cellular component biogenesis at cellular level
1.60 7.08e-15 GO:0046907 intracellular transport
1.97 8.14e-15 GO:0051325 interphase
1.98 1.05e-14 GO:0051329 interphase of mitotic cell cycle
1.25 8.66e-14 GO:0016043 cellular component organization
1.56 1.46e-13 GO:0033554 cellular response to stress
1.92 2.78e-13 GO:0006412 translation
1.84 5.80e-13 GO:0030163 protein catabolic process
1.88 9.29e-13 GO:0051603 proteolysis involved in cellular protein catabolic process
1.87 9.73e-13 GO:0044257 cellular protein catabolic process
1.53 1.05e-12 GO:0015031 protein transport
1.90 1.13e-12 GO:0006511 ubiquitin-dependent protein catabolic process
1.71 1.26e-12 GO:0034621 cellular macromolecular complex subunit organization
1.09 1.30e-12 GO:0009987 cellular process
1.30 1.32e-12 GO:0044249 cellular biosynthetic process
1.52 2.29e-12 GO:0045184 establishment of protein localization
1.88 2.37e-12 GO:0043632 modification-dependent macromolecule catabolic process
1.87 3.23e-12 GO:0019941 modification-dependent protein catabolic process
1.46 6.33e-12 GO:0008104 protein localization
1.28 2.61e-11 GO:0009058 biosynthetic process
1.43 3.10e-11 GO:0044248 cellular catabolic process
1.60 8.97e-11 GO:0006259 DNA metabolic process
1.79 1.47e-10 GO:0006281 DNA repair
1.80 1.48e-10 GO:0070647 protein modification by small protein conjugation or removal
1.39 1.77e-10 GO:0033036 macromolecule localization
1.85 1.16e-09 GO:0032446 protein modification by small protein conjugation
1.94 1.36e-09 GO:0071156 regulation of cell cycle arrest
1.36 1.49e-09 GO:0009056 catabolic process
1.75 2.01e-09 GO:0010564 regulation of cell cycle process
2.52 2.21e-09 GO:0071826 ribonucleoprotein complex subunit organization
1.31 2.68e-09 GO:0006464 protein modification process
2.16 2.94e-09 GO:0000082 G1/S transition of mitotic cell cycle
1.30 3.19e-09 GO:0043412 macromolecule modification
2.62 4.01e-09 GO:0006353 transcription termination, DNA-dependent
1.94 4.79e-09 GO:0000075 cell cycle checkpoint
1.60 5.44e-09 GO:0070727 cellular macromolecule localization
1.46 5.85e-09 GO:0043933 macromolecular complex subunit organization
1.85 7.12e-09 GO:0016567 protein ubiquitination
1.21 8.07e-09 GO:0060255 regulation of macromolecule metabolic process
2.52 9.65e-09 GO:0022618 ribonucleoprotein complex assembly
2.28 1.02e-08 GO:0051320 S phase
1.59 1.15e-08 GO:0034613 cellular protein localization
1.77 1.34e-08 GO:0048285 organelle fission
2.29 1.39e-08 GO:0000084 S phase of mitotic cell cycle
1.71 1.81e-08 GO:0051301 cell division
1.36 2.31e-08 GO:0051641 cellular localization
1.52 2.72e-08 GO:0051726 regulation of cell cycle
1.80 3.44e-08 GO:0034660 ncRNA metabolic process
1.41 3.89e-08 GO:0032774 RNA biosynthetic process
2.03 5.81e-08 GO:0010498 proteasomal protein catabolic process
2.03 5.81e-08 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process
1.65 5.92e-08 GO:0006886 intracellular protein transport
2.48 6.19e-08 GO:0000216 M/G1 transition of mitotic cell cycle
2.16 8.03e-08 GO:0042254 ribosome biogenesis
1.23 9.27e-08 GO:0010468 regulation of gene expression
1.73 1.33e-07 GO:0000087 M phase of mitotic cell cycle
1.74 1.86e-07 GO:0000280 nuclear division
1.74 1.86e-07 GO:0007067 mitosis
1.76 2.00e-07 GO:0010608 posttranscriptional regulation of gene expression
2.44 3.84e-07 GO:0006354 transcription elongation, DNA-dependent
2.35 3.88e-07 GO:0006415 translational termination
2.19 4.51e-07 GO:0032984 macromolecular complex disassembly
2.19 4.51e-07 GO:0034623 cellular macromolecular complex disassembly
1.17 4.58e-07 GO:0019222 regulation of metabolic process
1.18 5.31e-07 GO:0031323 regulation of cellular metabolic process
2.26 7.88e-07 GO:0043241 protein complex disassembly
2.26 7.88e-07 GO:0043624 cellular protein complex disassembly
1.35 9.07e-07 GO:0051649 establishment of localization in cell
2.21 1.58e-06 GO:0006414 translational elongation
1.56 3.04e-06 GO:0000279 M phase
1.22 4.03e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
2.28 5.02e-06 GO:0019080 viral genome expression
2.28 5.02e-06 GO:0019083 viral transcription
1.17 7.68e-06 GO:0080090 regulation of primary metabolic process
1.83 7.70e-06 GO:0034470 ncRNA processing
1.79 7.86e-06 GO:0033365 protein localization to organelle
1.59 1.38e-05 GO:0016568 chromatin modification
1.97 1.71e-05 GO:0048193 Golgi vesicle transport
2.47 1.73e-05 GO:0006368 transcription elongation from RNA polymerase II promoter
1.57 3.40e-05 GO:0034622 cellular macromolecular complex assembly
1.31 3.43e-05 GO:0044085 cellular component biogenesis
2.21 5.96e-05 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
2.15 6.04e-05 GO:0006364 rRNA processing
1.79 6.50e-05 GO:0022411 cellular component disassembly
1.79 6.50e-05 GO:0071845 cellular component disassembly at cellular level
1.20 6.88e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.56 7.40e-05 GO:0044419 interspecies interaction between organisms
2.96 7.75e-05 GO:0000245 spliceosome assembly
2.22 8.15e-05 GO:0051443 positive regulation of ubiquitin-protein ligase activity
1.36 8.19e-05 GO:0008219 cell death
2.02 8.64e-05 GO:0031398 positive regulation of protein ubiquitination
1.43 9.57e-05 GO:0071822 protein complex subunit organization
1.62 9.93e-05 GO:0006366 transcription from RNA polymerase II promoter
2.30 1.00e-04 GO:0072594 establishment of protein localization to organelle
1.83 1.18e-04 GO:0006417 regulation of translation
1.42 1.18e-04 GO:0051276 chromosome organization
2.02 1.19e-04 GO:0000077 DNA damage checkpoint
2.26 1.25e-04 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
1.35 1.36e-04 GO:0016265 death
1.90 1.36e-04 GO:0019058 viral infectious cycle
2.11 1.50e-04 GO:0051438 regulation of ubiquitin-protein ligase activity
2.08 1.68e-04 GO:0016072 rRNA metabolic process
2.19 1.83e-04 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.32 1.85e-04 GO:0071158 positive regulation of cell cycle arrest
2.65 1.90e-04 GO:0006369 termination of RNA polymerase II transcription
1.97 2.02e-04 GO:0031570 DNA integrity checkpoint
2.28 2.33e-04 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.20 2.50e-04 GO:0031123 RNA 3'-end processing
1.62 2.79e-04 GO:0007346 regulation of mitotic cell cycle
2.24 3.91e-04 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
1.37 3.95e-04 GO:0006915 apoptosis
2.41 4.67e-04 GO:0006521 regulation of cellular amino acid metabolic process
1.89 4.75e-04 GO:0007093 mitotic cell cycle checkpoint
1.76 5.26e-04 GO:0043687 post-translational protein modification
2.11 5.35e-04 GO:0051351 positive regulation of ligase activity
2.11 5.35e-04 GO:2000045 regulation of G1/S transition of mitotic cell cycle
1.79 5.40e-04 GO:0022415 viral reproductive process
2.17 5.56e-04 GO:0000209 protein polyubiquitination
2.30 5.88e-04 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.30 5.88e-04 GO:0072395 signal transduction involved in cell cycle checkpoint
2.30 5.88e-04 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.30 5.88e-04 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.30 5.88e-04 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.30 5.88e-04 GO:0072422 signal transduction involved in DNA damage checkpoint
2.30 5.88e-04 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.30 5.88e-04 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.17 6.85e-04 GO:0051171 regulation of nitrogen compound metabolic process
2.02 8.02e-04 GO:0051340 regulation of ligase activity
1.72 8.73e-04 GO:0006260 DNA replication
2.06 9.22e-04 GO:0030330 DNA damage response, signal transduction by p53 class mediator
1.36 9.27e-04 GO:0012501 programmed cell death
1.81 9.88e-04 GO:0031396 regulation of protein ubiquitination
2.11 1.01e-03 GO:0031575 mitotic cell cycle G1/S transition checkpoint
2.11 1.01e-03 GO:0071779 G1/S transition checkpoint
2.18 1.05e-03 GO:0051352 negative regulation of ligase activity
2.18 1.05e-03 GO:0051444 negative regulation of ubiquitin-protein ligase activity
1.88 1.65e-03 GO:0031018 endocrine pancreas development
1.36 1.70e-03 GO:0065003 macromolecular complex assembly
1.19 1.75e-03 GO:0051252 regulation of RNA metabolic process
1.17 1.92e-03 GO:0031326 regulation of cellular biosynthetic process
2.84 1.97e-03 GO:0000387 spliceosomal snRNP assembly
1.79 2.45e-03 GO:0031016 pancreas development
2.51 2.62e-03 GO:0006283 transcription-coupled nucleotide-excision repair
1.17 3.18e-03 GO:0009889 regulation of biosynthetic process
1.31 3.34e-03 GO:0006351 transcription, DNA-dependent
2.12 3.64e-03 GO:0006302 double-strand break repair
2.35 3.69e-03 GO:0050434 positive regulation of viral transcription
1.64 4.50e-03 GO:0006605 protein targeting
1.97 4.53e-03 GO:0006352 transcription initiation, DNA-dependent
2.16 6.01e-03 GO:0031124 mRNA 3'-end processing
1.77 8.09e-03 GO:0010565 regulation of cellular ketone metabolic process
2.12 9.51e-03 GO:0033238 regulation of cellular amine metabolic process
1.85 1.09e-02 GO:0042770 signal transduction in response to DNA damage
2.06 1.65e-02 GO:0006289 nucleotide-excision repair
1.16 1.71e-02 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.73 1.91e-02 GO:0007005 mitochondrion organization
2.17 2.16e-02 GO:0046782 regulation of viral transcription
2.87 2.39e-02 GO:0006360 transcription from RNA polymerase I promoter
2.87 2.39e-02 GO:0006361 transcription initiation from RNA polymerase I promoter
1.59 2.52e-02 GO:0006457 protein folding
2.61 2.65e-02 GO:0009452 RNA capping
1.82 2.76e-02 GO:0007059 chromosome segregation
1.17 3.12e-02 GO:0006355 regulation of transcription, DNA-dependent
2.06 3.14e-02 GO:0006367 transcription initiation from RNA polymerase II promoter
3.04 3.26e-02 GO:0006362 transcription elongation from RNA polymerase I promoter
1.89 3.46e-02 GO:0031397 negative regulation of protein ubiquitination
1.55 3.65e-02 GO:0009261 ribonucleotide catabolic process
1.38 3.75e-02 GO:0006325 chromatin organization
1.80 3.77e-02 GO:0090068 positive regulation of cell cycle process
1.44 4.47e-02 GO:0018193 peptidyl-amino acid modification
1.91 4.59e-02 GO:0051168 nuclear export
1.55 4.72e-02 GO:0009154 purine ribonucleotide catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.21 4.18e-99 GO:0044424 intracellular part
1.21 5.83e-99 GO:0005622 intracellular
1.25 1.88e-86 GO:0043229 intracellular organelle
1.28 2.80e-86 GO:0043227 membrane-bounded organelle
1.28 5.14e-86 GO:0043231 intracellular membrane-bounded organelle
1.25 6.77e-86 GO:0043226 organelle
1.36 3.29e-63 GO:0005634 nucleus
1.59 1.01e-48 GO:0044428 nuclear part
1.32 1.45e-48 GO:0044446 intracellular organelle part
1.31 3.72e-48 GO:0044422 organelle part
1.55 6.29e-44 GO:0070013 intracellular organelle lumen
1.52 1.88e-42 GO:0031974 membrane-enclosed lumen
1.60 8.11e-42 GO:0031981 nuclear lumen
1.52 2.55e-41 GO:0043233 organelle lumen
1.19 1.08e-35 GO:0005737 cytoplasm
2.02 3.32e-30 GO:0030529 ribonucleoprotein complex
1.34 3.94e-29 GO:0032991 macromolecular complex
1.23 5.93e-29 GO:0044444 cytoplasmic part
1.58 1.94e-27 GO:0005654 nucleoplasm
1.33 1.22e-20 GO:0043228 non-membrane-bounded organelle
1.33 1.22e-20 GO:0043232 intracellular non-membrane-bounded organelle
1.38 1.20e-19 GO:0005829 cytosol
1.81 6.89e-19 GO:0005730 nucleolus
2.54 4.10e-17 GO:0005681 spliceosomal complex
1.05 1.08e-13 GO:0044464 cell part
1.05 1.19e-13 GO:0005623 cell
1.26 2.48e-13 GO:0043234 protein complex
2.71 5.01e-12 GO:0071013 catalytic step 2 spliceosome
1.53 1.27e-11 GO:0044451 nucleoplasm part
1.57 6.09e-10 GO:0005694 chromosome
1.87 3.95e-09 GO:0016604 nuclear body
1.94 1.37e-08 GO:0005840 ribosome
1.95 3.74e-07 GO:0044445 cytosolic part
1.99 5.87e-07 GO:0000151 ubiquitin ligase complex
1.53 8.95e-07 GO:0044427 chromosomal part
1.30 1.10e-06 GO:0005739 mitochondrion
2.34 1.74e-06 GO:0022626 cytosolic ribosome
1.22 3.93e-06 GO:0031090 organelle membrane
2.35 1.87e-05 GO:0000502 proteasome complex
1.92 4.19e-05 GO:0016607 nuclear speck
1.37 4.92e-05 GO:0031967 organelle envelope
1.67 1.13e-04 GO:0000228 nuclear chromosome
1.30 1.32e-04 GO:0005794 Golgi apparatus
1.35 1.47e-04 GO:0031975 envelope
2.14 1.57e-04 GO:0016591 DNA-directed RNA polymerase II, holoenzyme
2.79 2.87e-04 GO:0030532 small nuclear ribonucleoprotein complex
2.06 3.10e-04 GO:0000790 nuclear chromatin
1.70 6.42e-04 GO:0044454 nuclear chromosome part
1.58 1.43e-03 GO:0005813 centrosome
1.74 1.85e-03 GO:0000793 condensed chromosome
2.21 2.36e-03 GO:0005798 Golgi-associated vesicle
1.32 2.91e-03 GO:0044429 mitochondrial part
1.35 2.95e-03 GO:0044431 Golgi apparatus part
1.70 4.14e-03 GO:0000775 chromosome, centromeric region
2.87 4.25e-03 GO:0005689 U12-type spliceosomal complex
2.09 5.01e-03 GO:0015934 large ribosomal subunit
1.44 5.41e-03 GO:0005815 microtubule organizing center
2.30 6.83e-03 GO:0015030 Cajal body
1.52 8.31e-03 GO:0000785 chromatin
1.50 1.07e-02 GO:0005635 nuclear envelope
1.85 1.20e-02 GO:0042470 melanosome
1.85 1.20e-02 GO:0048770 pigment granule
2.42 1.32e-02 GO:0022627 cytosolic small ribosomal subunit
1.29 1.43e-02 GO:0015630 microtubule cytoskeleton
2.00 1.73e-02 GO:0044450 microtubule organizing center part
1.57 1.76e-02 GO:0005819 spindle
1.81 3.08e-02 GO:0000776 kinetochore

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 1.71e-33 GO:0005515 protein binding
1.35 1.12e-29 GO:0003676 nucleic acid binding
1.11 5.88e-27 GO:0005488 binding
1.74 2.66e-26 GO:0003723 RNA binding
1.26 2.47e-08 GO:0008270 zinc ion binding
1.24 9.40e-08 GO:0003677 DNA binding
1.56 1.36e-07 GO:0016874 ligase activity
1.14 2.00e-07 GO:0003824 catalytic activity
1.23 3.11e-07 GO:0000166 nucleotide binding
1.76 8.48e-07 GO:0019787 small conjugating protein ligase activity
1.95 1.11e-06 GO:0003735 structural constituent of ribosome
1.77 1.59e-06 GO:0004842 ubiquitin-protein ligase activity
1.68 2.63e-06 GO:0016881 acid-amino acid ligase activity
1.64 3.11e-06 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.22 3.43e-05 GO:0017076 purine nucleotide binding
1.22 4.15e-05 GO:0035639 purine ribonucleoside triphosphate binding
1.22 7.10e-05 GO:0032553 ribonucleotide binding
1.22 7.10e-05 GO:0032555 purine ribonucleotide binding
1.18 3.10e-04 GO:0046914 transition metal ion binding
1.34 3.11e-04 GO:0019899 enzyme binding
1.23 3.17e-04 GO:0030554 adenyl nucleotide binding
1.23 4.16e-04 GO:0032559 adenyl ribonucleotide binding
1.23 4.30e-04 GO:0005524 ATP binding
1.79 6.87e-04 GO:0004386 helicase activity
2.03 1.02e-03 GO:0008135 translation factor activity, nucleic acid binding
1.70 1.04e-03 GO:0008168 methyltransferase activity
1.32 1.07e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.32 1.14e-03 GO:0016462 pyrophosphatase activity
1.32 1.39e-03 GO:0017111 nucleoside-triphosphatase activity
1.31 1.50e-03 GO:0016817 hydrolase activity, acting on acid anhydrides
1.44 3.11e-03 GO:0003712 transcription cofactor activity
1.44 3.64e-03 GO:0000988 protein binding transcription factor activity
1.44 3.64e-03 GO:0000989 transcription factor binding transcription factor activity
1.65 3.66e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.51 4.17e-03 GO:0042623 ATPase activity, coupled
1.19 6.35e-03 GO:0016740 transferase activity
1.43 1.03e-02 GO:0016887 ATPase activity
1.80 1.06e-02 GO:0008026 ATP-dependent helicase activity
1.80 1.06e-02 GO:0070035 purine NTP-dependent helicase activity
1.85 2.59e-02 GO:0008565 protein transporter activity
1.72 3.25e-02 GO:0051082 unfolded protein binding
2.15 3.50e-02 GO:0003743 translation initiation factor activity